Mitochondrial Myopathy
A group of diseases that affect the mitochondria and interfere with teh functioning of the muscles. Known diseases in this group are comprised of Kearns-Sayre syndrome (KSS) ; Leigh's syndrome ; mitochondrial DNA depletion syndrome (MDS) ; mitochondrial encephalomyopathy, lactic acidosis and strokelike episodes (MELAS) ; myoclonus epilepsy with ragged red fibers (MERRF) ; mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) ; neuropathy, ataxia and retinitis pigmentosa (NARP) ; Pearson syndrome; and progressive external ophthalmoplegia (PEO). Though there are many degrees of progression and severity, some of these diseases may result in skeletal muscle abnormalities, poor muscle tone, nervous system impairment, eye problems, cardiac abnormalities,and affect other body systems, potentially leading to gastrointestinal issues, seizures, inability to walk, mobility impairment, and may affect the functioning of the brain. Usually inherited through the maternal mitochondrial gene.
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